CONTENTS The Guest Editors vii Preface viii Introduction ix 1. Lung cancer: oncogenesis and prevention 1 N. van Zandwijk 2. Pathology and immunohistochemistry of lung cancer 15 E. Brambilla, S. Lantuejoul 3. Pre-invasive diseases of the lung 36 D.T. Merrick, F.R. Hirsch 4. Screening for lung cancer 57 D.E. Midthun, J.R. Jett 5. Symptoms and signs of lung cancer 71 N. Navani, S.G. Spiro 6. The biology of lung cancer 88 M.H. Lawson, T. Eisen 7. Radiology of lung cancer 106 M.N. Taylor, P. Shaw 8. Diagnostic endoscopic investigations in lung cancer 136 N. Navani, S.M. Janes 9. Staging of lung cancer 150 J-P. Sculier 10. Functional evaluation for treatment 169 C.F.N. Koegelenberg, D. Plekker, C.T. Bolliger 11. The surgical treatment of lung cancer 187 E. Potton, S.M. Janes, S.G. Spiro 12. Radiotherapy in the treatment of nonsmall cell lung cancer 207 M.Q.F. Hatton, J. Martin 13. Neoadjuvant and adjuvant treatment for operable nonsmall cell 244 lung cancer M. Mukesh, D. Gilligan The European Respiratory Monograph Number 44 June 2009 Contents MON 44.qxd 03/06/2009 12:57 Page 1