Contents Foreword vii Preface ix Guest Editors x Introduction xiii List of abbreviations xviii 1. International efforts to reverse and end the tuberculosis pandemic: 1 past, present and future global strategies Guy B. Marks, Alvin Kuo Jing Teo, Emily B. Wong, Greg J. Fox and Thu Anh Nguyen 2. Epidemiology: the current burden of tuberculosis and its determinants 18 Rita Verstraeten, Marta Cossa, Leonardo Martinez, Kristin Nelson, Dinis Nguenha and Alberto L. García-Basteiro 3. Host–pathogen interactions in the context of tuberculosis infection 34 and disease Delia Goletti, Alessandra Aiello, Leopold D. Tientcheu, Caleb Muefong, Ting Huey Hu, Paula Niewold, Simone A. Joosten, Catherine W.M. Ong and Jayne S. Sutherland Diagnosis of tuberculosis 4. Clinical presentation of pulmonary and extrapulmonary tuberculosis 51 Onno W. Akkerman, Gunar Guenther, Marcela Munoz-Torrico, Aylin Babalik, Jan Heyckendorf, Antonia Morita Iswari Saktiawati, Jean-Pierre Zellweger, Pedro Sousa and Füsun Öner Eyúboğlu 5. Microbiological tests and laboratory tests: the value of 64 point-of-care testing Elisa Tagliani, Francesca Saluzzo and Daniela Maria Cirillo 6. The evolution of imaging and portable imaging tools to aid 78 tuberculosis diagnosis Jacob Bigio, Claudia M. Denkinger, Rigveda Kadam, Mikashmi Kohli, Giorgia Sulis, César Ugarte-Gil, Seda Yerlikaya and Madhukar Pai 7. The differential diagnosis of thoracic tuberculosis: a guide to 90 under- and over-diagnosis Graham H. Bothamley, Grace Adeoye, Jan Heyckendorf, Joe Rowan and Abhinav Singla ERS monograph The Challenge of Tuberculosis in the 21st Century Number 101 September 2023