CONTENTS The Guest Editors vii Preface viii Introduction ix 1. Interstitial lung diseases today 1 U. Costabel, T.E. King Jr Current challenges and open questions 2. Exercise testing in interstitial lung disease diagnosis and management 7 M.K. Han, F.J. Martinez 3. Diagnosing idiopathic interstitial pneumonias: utility of surgical lung 24 biopsy S.K. Huang, J.L. Myers, K.R. Flaherty 4. The role of bronchoalveolar lavage cellular analysis in the diagnosis 36 of interstitial lung diseases P. Spagnolo, L. Richeldi, G. Raghu 5. The role of biomarkers in management of interstitial lung disease: 47 implications of biomarkers derived from type II pneumocytes T. Nukiwa 6. Clinical trials in interstitial lung disease 67 J. Behr, P.W. Noble Diseases 7. Idiopathic interstitial pneumonias 87 A. Ferreira, H.R. Collard 8. Extrinsic allergic alveolitis 112 C. Diego, P. Cullinan 9. Sarcoidosis 126 J.C. Grutters, M. Drent, J.M.M. van den Bosch 10. Pulmonary Langerhans' cell histiocytosis 155 S. Harari, A. Caminati 11. Lymphangioleiomyomatosis 176 D. Clements, W.Y.C. Chang, S.R. Johnson The European Respiratory Monograph Number 46 December 2009 Contents MON 46.qxd 04/12/2009 12:53 Page 1