Published by European Respiratory Society Journals Ltd ©2009 December 2009 Hardback ISBN: 978-1-904097-72-3 Paperback ISBN: 978-1-904097-73-0 Online ISBN: 978-1-904097-97-6 Print ISSN: 1025-448x Online ISSN: 2075-6674 Printed by Latimer Trend & Co. Ltd, Plymouth, UK Managing Editors: Pippa Powell, Fiona Marks and Catherine Pumphrey, European Respiratory Society Journals Ltd, Publications Office, 442 Glossop Road, Sheffield, S10 2PX, UK. Tel: 44 114 2672860 Fax: 44 114 2665064 E-mail: Monograph@ersj.org.uk All material is copyright to European Respiratory Society Journals Ltd. It may not be reproduced in any way including electronic means without the express permission of the company. Statements in the volume reflect the views of the authors, and not necessarily those of the European Respiratory Society, editors or publishers. Mon 46 page iv.qxd 04/12/2009 13:00 Page 1