Contributors vii Preface xi Get more from this Handbook xii List of abbreviations xiii Chapter 1 -Physiology and anatomy of sleep and breathing Neuroanatomy and neurobiology of sleep 1 Mary J. Morrell, Paolo Palange, Patrick Levy and Wilfried De Backer Breathing during sleep and wakefulness 6 Mary J. Morrell, Paolo Palange, Patrick Levy and Wilfried De Backer Homeostatic regulation during sleep 13 Mary J. Morrell, Paolo Palange, Patrick Levy and Wilfried De Backer Chapter 2 -Respiratory conditions Definitions of sleep disordered breathing 21 Johan Verbraecken Obstructive sleep apnoea syndrome 25 Johan Verbraecken Obstructive sleep apnoea: epidemiology and risk factors 26 Johan Verbraecken Obstructive sleep apnoea: pathophysiology 29 Johan Verbraecke and Wilfried de Backer Obstructive sleep apnoea: clinical aspects 32 Stefan Andreas Obstructive sleep apnoea: consequences 35 Stefan Andreas Central sleep apnoea and Cheyne–Stokes respiration 39 Winfried Randerath Contents