Metastatic tumours 477 Elisabeth Quoix Pleural and chest wall tumours 482 Arnaud Scherpereel Mediastinal tumours 489 Paul E. Van Schil, Patrick Lauwers and Jeroen M. Hendriks Chapter 15 – Sleep-related disorders Obstructive sleep apnoea/hypopnoea syndrome 491 Wilfried De Backer Central sleep apnoea 498 Konrad E. Bloch and Thomas Brack Hypoventilation syndromes 503 Jean-François Muir Chapter 16 – Immunodeficiency/orphan lung disorders Pulmonary diseases in primary immunodeficiency syndromes 509 Federica Pulvirenti, Cinzia Milito, Maria Anna Digiulio and Isabella Quinti HIV-related disease 513 Marc C.I. Lipman and Rob F. Miller Graft versus host diseases 521 Federica Pulvirenti, Cinzia Milito, Maria Anna Digiulio and Isabella Quinti Amyloidosis 526 Helen J. Lachmann