Table of contents Contributors xii Preface xvii Get more from this Handbook xviii List of abbreviations xxix Chapter 1 – Structure and function of the respiratory system Anatomy and development of the respiratory system 1 Robert Dinwiddie Applied respiratory physiology 11 Caroline Beardsmore and Monika Gappa Immunology and defence mechanisms 19 Diana Rädler and Bianca Schaub Environmental determinants of childhood respiratory health 29 and disease Erik Melén and Matthew S. Perzanowski Chapter 2 – Respiratory signs and symptoms History and physical examination 33 Michael B. Anthracopoulos, Kostas Douros and Kostas N. Priftis Cough 44 Ahmad Kantar, Michael Shields, Fabio Cardinale and Anne B. Chang Tachypnoea, dyspnoea, respiratory distress and chest pain 50 Josef Riedler Snoring, hoarseness, stridor and wheezing 57 Kostas N. Priftis, Kostas Douros and Michael B. Anthracopoulos Exercise intolerance 65 Kai-Håkon Carlsen Chapter 3 – Pulmonary function testing and other diagnostic tests Static and dynamic lung volumes 70 Oliver Fuchs