12. Diagnosis, classification and epidemiology of pulmonary 204 nontuberculous mycobacterial disease Timothy M. Baird and Rachel Thomson 13. Management of pulmonary nontuberculous mycobacteria disease 222 Steven Cowman and Michael R. Loebinger 14. Nontuberculous mycobacteria infections in patients receiving 238 immunosuppressive agents Gregory P. Ranches and Kevin L. Winthrop 15. Systemic and connective tissue diseases 254 Anthony De Soyza 16. Diagnosis of primary ciliary dyskinesia: current practice and future 267 perspectives Amelia Shoemark and Jane S. Lucas 17. Management of primary ciliary dyskinesia: current practice and future 282 perspectives Claudia E. Kuehni, Myrofora Goutaki, Bruna Rubbo and Jane S. Lucas 18. Management of frequently exacerbating patients 300 Andrea Gramegna, Marta Di Pasquale and Francesco Blasi 19. Antibiotic management and resistance 312 Eva Polverino and Javier Perez-Miranda 20. Airway clearance techniques, pulmonary rehabilitation and 331 physical activity Beatriz Herrero-Cortina, Annemarie L. Lee, Brenda O’Neill and Judy Bradley 21. Site of care and multidisciplinary approach 353 Francesco Amati, Andrea Gramegna, Martina Contarini, Paolo Tarsia, Angela Bellofiore, Francesco Blasi and Stefano Aliberti 22. Future directions: the next 10 years in research 371 Sanjay H. Chotirmall Case 1 388 Andrea Gramegna Case 2 391 Diego Jose Maselli Case 3 396 Jessica Rademacher Case 4 399 Margarida Redondo Case 5 403 Patricia Chang-Macchiu and Eva Polverino Case 6 409 Guillermo Suarez-Cuartin