Contents Preface ix Guest Editors x Introduction xiii List of abbreviations xvii 1. A patient’s perspective 1 Marta Almagro Manero and Jeanette Boyd 2. Pathophysiology 8 Rita Boaventura, Amelia Shoemark and James D. Chalmers 3. Identifying undiagnosed cystic fibrosis in adults with bronchiectasis 29 Carlo Castellani and Nicholas J. Simmonds 4. Comorbidities and their impact 45 Melissa J. McDonnell, Chris Ward and Robert M. Rutherford 5. Defining severe bronchiectasis 62 Josje Altenburg and Pieter C. Goeminne 6. The bronchiectasis microbiome 82 Geraint B. Rogers 7. How do we know what works? Clinical trial end-points and quality 99 of life assessment William R. Good, Lata Jayaram, Alain C. Vandal and Conroy A. Wong 8. Phenotypes and endotypes 133 James D. Chalmers 9. Primary immunodeficiency 153 David M. Lowe and John R. Hurst 10. COPD and asthma overlap with bronchiectasis 167 Federico L. Dente, Maria Adelaide Roggi, Roberta Del Cesta, Eva Polverino and Pierluigi Paggiaro 11. Fungal lung disease 186 Heather Green, Pippa Newton and Andrew M. Jones ERS monograph Bronchiectasis Number 81 September 2018