Contents Preface ix Guest Editors x Introduction xiv List of abbreviations xviii 1. The patients’ perspective 1 Gabi Spita, Helen Clegg, Marius Dumitru, Paul Sommerfeld, Courtney Coleman and Pippa Powell 2. History of tuberculosis 8 Robert Loddenkemper, John F. Murray, Christoph Gradmann, Philip C. Hopewell and Midori Kato-Maeda 3. Epidemiology and socioeconomic determinants 28 Raquel Duarte, João V. Santos, André Santos Silva and Giovanni Sotgiu 4. Evolution of the strategies for control and elimination 36 Mario C. Raviglione 5. Aetiopathogenesis, immunology and microbiology 62 Palmira Barreira-Silva, Egídio Torrado, Hanna Nebenzahl-Guimaraes, Gunilla Kallenius and Margarida Correia-Neves 6. Clinical diagnosis 83 Jean-Pierre Zellweger, Pedro Sousa and Jan Heyckendorf 7. Laboratory diagnosis 99 Elisa Tagliani, Vlad Nikolayevskyy, Enrico Tortoli and Daniela Maria Cirillo 8. Imaging for diagnosis and management 116 Dumitru Chesov and Victor Botnaru 9. Bronchoscopy and other invasive procedures for diagnosis 137 Angshu Bhowmik and Felix J.F. Herth 10. Treatment of drug-susceptible and drug-resistant tuberculosis 152 José A. Caminero, Anna Scardigli, Tijp van der Werf and Marina Tadolini ERS monograph Tuberculosis Number 82 December 2018