ERS | monograph Introduction Giovanni Battista Migliori1, Graham Bothamley2,3,4, Raquel Duarte5,6,7 and Adrian Rendon8 @ERSpublications Physicians feel TB is either very easy to treat with standard regimens or is too complex. This book: provides trainees with basic TB management knowledge offers insight into addressing complexities in individual patients is a useful resource for experts. On 26 September 2018, the United National General Assembly agreed to take concerted action on TB. With over 10 million new TB cases (90% in adults and 9% in HIV co-infected individuals) and 1.6 million deaths (300000 in HIV coinfected persons) in 2017, TB is a global health priority [1]. Of particular concern for both clinicians and national TB programmes is MDR-TB: in 2017, WHO were notified of 558000 new rifampicin-resistant cases and 460000 confirmed MDR-TB cases [1]. Heads of state and government agreed to mobilise US$13 billion a year by 2022 in order to ensure that TB care is received by 40 million people and preventive treatment is given to 30 million people [2]. Although the “white plague” has historically been studied in an extensive manner (it was “the” respiratory disease in the pre-antibiotic era), there is still much to learn about its prevention, diagnosis and treatment. TB is therefore a hot topic in respiratory medicine, attracting an increasing amount of interest from clinicians, scientists, public health officers and the pharmaceutical industry, given that new drugs are finally available after more than 40 years of neglect. The High-Level Meeting on the Fight to End Tuberculosis also agreed to fund a US$2-billion research agenda [2]. With this Monograph, our aim is to provide an accessible resource that will help the young physician in training to recognise and treat TB in all its manifestations, as well as address a need for help with other mycobacterial diseases which might become apparent during the diagnostic process. Primarily providing clinical support, this book will also act as a reference resource for difficult TB. It will introduce topics of interest and scientific advances in TB that can be investigated by the interested reader at their leisure. Many of the chapters also indicate where TB management is going. Copyright ©ERS 2018. Print ISBN: 978-1-84984-099-6. Online ISBN: 978-1-84984-100-9. Print ISSN: 2312-508X. Online ISSN: 2312-5098. Correspondence: Giovanni Battista Migliori, Istituti Clinici Scientifici Maugeri IRCCS, Via Roncaccio 16, Tradate, Varese, 21049, Italy. E-mail: 1 Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. 2 Homerton University Hospital, London, UK. 3 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. 4 London School of Hygiene and Tropical Medicine, London, UK. 5 Departamento de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal. 6 Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal. 7 ISPUP-EPIUnit, Faculdade de Medicina, Universidade do Porto, Porto, Portugal. 8 TB Dept, University Hospital of Monterrey, Monterrey, Mexico. xiv
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