PUBLISHED BY THE EUROPEAN RESPIRATORY SOCIETY EDITORS Konrad E. Bloch with Thomas Brack and Anita K. Simonds AUTHORS AND REVIEWERS ERS STAFF Alice Bartlett, Matt Broadhead, May Elphinstone, Jonathan Hansen, Catherine Pumphrey, David Sadler © 2015 European Respiratory Society Design by Claire Turner, Lee Dodd and Ben Watson, ERS Typeset in India by TechSet Composition Ltd Printed in the UK by Latimer Trend and Company Ltd All material is copyright to the European Respiratory Society. It may not be reproduced in any way including electronically without the express permission of the society. CONTACT, PERMISSIONS AND SALES REQUESTS: European Respiratory Society, 442 Glossop Road, Sheffield, S10 2PX, UK Tel: 44 114 2672860 Fax: 44 114 2665064 e-mail: info@ersj.org.uk ISBN 978-1-84984-07-4 Ferran Barbé Thomas Brack Dragos Bumbacea Richard Costello Mina Gaga Ildikó Horváth Kostas Kostikas Christian M. Lo Cascio Winfried Randerath Anita K. Simonds Frank Smeenk Robert Thurnheer Silvia Ulrich Somaini Eleftherios Zervas