CONTENTS The Guest Editors vii Preface viii Introduction ix 1. Definition and history of sarcoidosis 1 O.P. Sharma 2. Epidemiology of Sarcoidosis 13 M. Thomeer, M. Demedts, W. Wuyts 3. Aetiologies of sarcoidosis 23 L.S. Newman 4. Immunology and pathophysiology 49 G. Semenzato, M. Bortoli, E. Brunetta, C. Agostini 5. Genetics 64 R.M. du Bois, P.A. Beirne, S.E. Anevlavis 6. Pathology 82 V. Poletti, G. Casoni, M. Chilosi 7. Fatigue, quality of life and health status in sarcoidosis 92 J. De Vries, R.M. Wirnsberger 8. Pulmonary sarcoidosis 105 J.P. Lynch 3rd, E.S. White 9. Cardiac involvement in sarcoidosis 130 W. Schulte, D. Kirsten, M. Drent, U. Costabel 10. Skin manifestation in sarcoidosis 150 A. Eklund, G. Rizzato 11. Neurosarcoidosis 164 E. Hoitsma, O.P. Sharma 12. Clinical aspects of ocular sarcoidosis 188 K. Ohara, M.A. Judson, R.P. Baughman 13. Sarcoidosis: joint, muscle and bone involvement 210 T.L.Th.A. Jansen, P.P.M.M. Geusens The European Respiratory Monograph Number 32 September 2005 Contents MON 32.qxd 18/08/2005 16:39 Page 1