Respiratory Diseases in Infants and Children Page vi (7 of 371)

13. Asthma in school-aged children and adolescents 191 J.H. Wildhaber, F.H. Sennhauser, P.L.P. Brand 14. Bronchopulmonary dysplasia: current models and concepts 217 A. Greenough, S. Kotecha, E. Vrijlandt 15. Cystic fibrosis 234 A. Bush, M. Götz 16. Current issues in the basic mechanisms, pathophysiology, diagnosis and 291 management of primary ciliary dyskinesia T. Ferkol, H.M. Mitchison, C. O’Callaghan, M. Leigh, J. Carson, H. Lie, D. Rosenbluth, S.L. Brody 17. Adipositas in infants and children: a new disease on the horizon 314 K.G. Tantisira, D.R. Gold 18. New approaches to the understanding of complex chronic lung diseases 345 U. Frey, G.N. Maksym, M. Silverman, B. Suki Contents MON 37.qxd 07/11/2006 14:31 Page 2

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13. Asthma in school-aged children and adolescents 191 J.H. Wildhaber, F.H. Sennhauser, P.L.P. Brand 14. Bronchopulmonary dysplasia: current models and concepts 217 A. Greenough, S. Kotecha, E. Vrijlandt 15. Cystic fibrosis 234 A. Bush, M. Götz 16. Current issues in the basic mechanisms, pathophysiology, diagnosis and 291 management of primary ciliary dyskinesia T. Ferkol, H.M. Mitchison, C. O’Callaghan, M. Leigh, J. Carson, H. Lie, D. Rosenbluth, S.L. Brody 17. Adipositas in infants and children: a new disease on the horizon 314 K.G. Tantisira, D.R. Gold 18. New approaches to the understanding of complex chronic lung diseases 345 U. Frey, G.N. Maksym, M. Silverman, B. Suki Contents MON 37.qxd 07/11/2006 14:31 Page 2

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Previously published in the European Respiratory Monograph Series: Respiratory Emergencies, Monograph 36 Edited by S Nava, T Welte (2006) Cystic Fibrosis, Monograph 35 Edited by A K Webb, F A Ratjen (2006) Pulmonary Manifestations of Systemic Diseases, Monograph 34 Edited by G M Verleden, M G Demedts, R Westhovens, M Thomer (2005) Diagnosis, Prevention and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports, Monograph 33 Edited by K-H Carlsen, L Delgado, S Del Giacco (2005) Sarcoidosis, Monograph 32 Edited by M Drent, U Costabel (2005) Lung Function Testing, Monograph 31 Edited by R Gosselink, H Stam (2005) Imaging, Monograph 30 Edited by A Bankier, P A Gevenosis (2004) Surgery for Non-Neoplastic Disorders of the Chest: a Clinical Update, Monograph 29 Edited by G M Verleden, D Van Raemdonck, T Lerut, M Demedts (2004) Antibiotics and the Lung, Monograph 28 Edited by M Cazzola, F Blasi, S Ewig (2004) Pulmonary Vascular Pathology: A Clinical Update, Monograph 27 Edited by M Demedts, M Delcroix, R Verhaeghe, G M Verleden (2004) Lung Transplantation, Monograph 26 Edited by J Boe, M Estenne, W Weder (2003) Respiratory Diseases in Women, Monograph 25 Edited by C Mapp, S Buist (2003) Nutrition and Metabolism in Respiratory Disease, Monograph 24 Edited by J Boe, M Estenne, W Weder (2003) Asthma, Monograph 23 Edited by F Chung, L M Fabbri (2003) Pleural Diseases, Monograph 22 Edited by R Loddenkemper, V B Antony (2002) The Impact of Air Pollution on Respiratory Health, Monograph 21 Edited by G D'Amato, S T Holgate (2002) ARDS, Monograph 20 Edited by T W Evans, M J D Griffiths, B F Keogh (2002) Growing up with Lung Disease: The Lung in Transition to Adult Life, Monograph 19 Edited by A Bush, K-H Carlsen, M S Zach (2002) The Nose and Lung Diseases, Monograph 18 Edited by B Wallaërt, PChanex, PGodard (2001) Lung Cancer, Monograph 17 Edited by S G Spiro (2001) Noninvasive Mechanical Ventilation, Monograph 16 Edited by J-F Muir, N Ambrosino, A K Simonds (2001) Interstitial Lung Diseases, Monograph 14 Edited by D Olivieri, R M du Bois (2000) Pulmonary Rehabilitation, Monograph 13 Edited by C F Donner, M Decramer (2000) Respiratory Mechanics, Monograph 12 Edited by J Milic-Emili (1999) Occupational Lung Disorders, Monograph 11 Edited by C E Mapp (1999) Respiratory Disorders During Sleep, Monograph 10 Edited by W T McNicholas (1998) Pulmonary Endoscopy, Monograph 9 Edited by J Strausz (1998) Mechanical Ventilation from Intensive Care to Home Care, Monograph 8 Edited by C Roussos (1998) Management of COPD, Monograph 7 Edited by D S Postma, N M Siafakas (1998) Monographs may be purchased from: Publications Sales Department, Maney Publishing, Suite 1C, Joseph’s Well, Hanover Walk, Leeds, LS3 1AB, UK. Tel: 44 (0)113 2432800 Fax: 44 (0)113 3868178 E-mail: books@maney.co.uk www.maney.co.uk Customers in the Americas should contact: Old City Publishing Inc., 628 North 2nd Street, Philadelphia PA 19123, USA. Tel: 1 215 925 4390 Fax: 1 215 925 4371 E-mail: info@oldcitypublishing.com monograph list.qxd 27/10/2006 11:05 Page 1

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CONTENTS The Guest Editors vii Preface viii Introduction ix 1. Epidemiology of respiratory diseases in infants and children 1 E. von Mutius 2. Lung development from infancy to adulthood 8 P.J.F.M. Merkus, A.A. Hislop 3. Assessing lung growth and function in infants and young children 22 M. Gappa, J. Stocks, U. Frey 4. Remodelling in paediatric respiratory disease and impact on growth 41 and development D.N. Payne, S. Saglani, A. Bush 5. Immunology and defence mechanism of the developing lung 60 B. Schaub, R. Lauener, S.L. Prescott 6. Allergy and the paediatric lung during development 79 A. Custovic, K.C. Lødrup Carlsen, K. Håkon Carlsen 7. Impact of genetic factors on lung development in health and disease 93 P. LeSouëf, M. Kabesch 8. Gene–environment interaction and respiratory disease in children 108 J. Gerritsen, N.E. Reijmerink, M. Kerkhof, D.S. Postma 9. Clinically relevant early functional and diagnostic markers of lung 120 disease in children J.C. de Jongste, E. Baraldi, E. Lombardi 10. Clinically relevant early functional and diagnostic markers of lung disease 142 in the paediatric intensive care unit A. Schibler, J.J. Pillow 11. Wheezing disorders in young children: one disease or several phenotypes? 153 J. Grigg, M. Silverman 12. Bronchiolitis in infants and children 170 J.LL. Kimpen, J. Hammer The European Respiratory Monograph Number 37 November 2006 Contents MON 37.qxd 07/11/2006 14:31 Page 1

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