Contents Guest Editors v Preface vi Introduction vii 1. Pulmonary vascular disease: an historical perspective 1 Tim Higenbottam 2. Pulmonary hypertension: diagnosis, differential diagnosis and pitfalls 17 Anton Vonk Noordegraaf, Harm Jan Bogaard, Joanne A. Groeneveldt, Esther J. Nossent, Anco Boonstra and Adam Torbicki 3. Current medical therapies in pulmonary arterial hypertension 26 Nazzareno Galiè, Alessandra Manes and Massimiliano Palazzini 4. Pulmonary arterial hypertension in connective tissue diseases 42 Paul M. Hassoun, Britta Maurer and Oliver Distler 5. Portopulmonary hypertension: a consequence of portal hypertension 58 Michael J. Krowka and Roberto Rodriguez-Roisin 6. Managing pulmonary hypertension in patients with congenital 71 heart disease Damien Bonnet and Marilyne Lévy 7. Pulmonary arterial hypertension in patients with HIV infection 82 Harrison W. Farber 8. Pulmonary hypertension in children 94 Shinichi Takatsuki, Maurice Beghetti and David Dunbar Ivy 9. Chronic thromboembolic pulmonary hypertension 108 Diana Bonderman and Irene M. Lang 10. Pulmonary hypertension associated with left heart disease 119 Yochai Adir and Off er Amir 11. Pulmonary hypertension in patients with COPD 138 Ari Chaouat and Omar A. Minai Number 57 September 2012