Contents Preface v Guest Editors vii Introduction ix Outcomes in clinical trials: specific disease areas 1. Chronic obstructive pulmonary disease 1 Emiel F.M. Wouters 2. Asthma 19 Julia Koopmans and Christian Taube 3. Idiopathic pulmonary fibrosis 37 Toby M. Maher 4. Cystic fibrosis 54 Reshma Amin and Felix Ratjen 5. Pulmonary arterial hypertension 70 Gabor Kovacs and Horst Olschewski 6. The intensive care unit 85 Donald M. Arnold and Deborah J. Cook Outcomes in clinical trials: specific outcomes 7. Biomarkers 90 Jonas Schupp and Antje Prasse 8. Health status measurement 96 Paul W. Jones 9. Electronic patient-reported outcomes 105 Sonya Ludmilla Eremenco 10. Physical activity 117 Henrik Watz Number 62 December 2013