Alveolar stem cells and their niche 10. Alveolar epithelial stem cells in homeostasis and repair 122 Andrea Toth, Barbara Zhao and William J. Zacharias 11. Mesenchymal cells, immune cells and the lung stem cell niche 134 Andrew J. Thorley and Jason R. Rock 12. Endothelial cells in the lung 144 Lisandra Vila Ellis, Celine Shuet Lin Kong and Jichao Chen Modelling the lung and stem cell function 13. The Human Lung Cell Atlas: a transformational resource for cells 158 of the respiratory system Kerstin B. Meyer, Anna Wilbrey-Clark, Martijn Nawijn and Sarah A. Teichmann 14. Lung organoids: powerful tools for studying lung stem cells and diseases 175 Hiroaki Katsura and Brigid L.M. Hogan 15. Induced pluripotent stem cells for generating lung airway stem cells 190 and modelling respiratory disease Jake Le Suer, Rosemary Sease, Finn Hawkins and Amy L. Ryan 16. Induced pluripotent stem cells for generating lung alveolar epithelial 205 cells and modelling respiratory disease Jessie Huang and Darrell N. Kotton 17. Three-dimensional tissue-based models for translational lung stem 222 cell research: precision-cut lung slices Charlotte Dean and Melanie Königshoff 18. The use of pre-conditioning and novel assays in the development of 232 protocols for transplantation of lung progenitors Chava Rosen and Yair Reisner 19. Lung tissue bioengineering for transplantation and modelling of 248 development, disease and regeneration Martina M. De Santis, Federica Michielin, Soichi Shibuya, Paolo de Coppi and Darcy E. Wagner 20. Ferret respiratory disease models for the study of lung stem cells 273 Albert C. Pai, Kalpaj R. Parekh, John F. Engelhardt and Thomas J. Lynch Lung stem cells and disease 21. Epithelial stem cells at the intersection of tissue regeneration and 290 pulmonary fibrosis Manuela Platé, Yoshihiko Kobayashi, Rachel C. Chambers and Purushothama Rao Tata 22. Lung stem cells and therapy for cystic fibrosis 306 Sriram Vaidyanathan, Matthew McCarra and Tushar J. Desai