12. Mediastinal staging 159 Christophe Dooms, Herbert Decaluwe and Paul De Leyn 13. Approaches in patients with locally advanced NSCLC: a surgeon’s 167 perspective Paul E. Van Schil, Michèle De Waele, Jeroen M. Hendriks and Patrick R. Lauwers 14. Approaches in patients with locally advanced NSCLC: a radiation 178 oncologist’s perspective Dirk De Ruysscher, Stéphanie Peeters and Esther G.C. Troost 15. Chemotherapy 186 Adam Januszewski and Sanjay Popat 16. Systemic treatment of elderly patients 202 Charlotte Leduc and Elisabeth Quoix 17. Achievements in targeted therapies 215 Paolo Bironzo, Teresa Mele and Silvia Novello 18. Can we expect progress from targeted therapy of SCLC? 234 Nevin Murray and Krista L. Noonan 19. Immunotherapy 247 Niels Reinmuth and David F. Heigener 20. Perspective of a pulmonologist: what might we expect and what do 261 we need to know? Nicolas Guibert, Elise Noel-Savina and Julien Mazières