16.4 Big data and artificial intelligence: opportunities and 364 challenges Renaud Tamisier, Sébastien Bailly and Jean-Louis Pépin 16.5 Patient empowerment/participation in care of respiratory 367 sleep disorders Piet-Heijn van Mechelen 17 – Paediatric respiratory sleep medicine 17.1 Development of breathing and sleep, and pathophysiology 370 of apnoea in the first years of life Refika Ersu and Ha Trang 17.2 Sleep disordered breathing in children 376 Refika Ersu and Ha Trang 17.3 Comorbid respiratory disorders in children 382 Stijn Verhulst and Brigitte Fauroux 17.4 Clinical assessment and diagnostic techniques 386 Maria Pia Villa and Stijn Verhulst 17.5 Management of sleep-related respiratory disorders in children 396 Athanasios G. Kaditis, Maria Pia Villa, Anita K. Simonds, Stijn Verhulst and Brigitte Fauroux