Contents Preface v Guest Editors vii Introduction ix List of abbreviations xiv 1. Respiratory failure: a patient’s perspective and clinical cases 1 Francesco Amati, Annalisa Vigni, Sofia Misuraca, Francesco Bindo, Andrea Gramegna, Antonio Voza, Francesco Blasi and Stefano Aliberti 2. Epidemiology: global spread, risk factors for disease incidence, 14 severity and mortality Joan B. Soriano and Alberto Infante 3. Historical perspective: other human coronavirus infectious diseases, 28 SARS and MERS David S. Hui and Alimuddin Zumla 4. Drug repurposing and other strategies for rapid antiviral 39 development: lessons from the early stage of the pandemic Sophie O’Reilly, Matthew Angeliadis, Ross Murtagh and Virginie W. Gautier 5. Can the immune system be targeted to treat COVID-19? 69 Sarah Abdelhafeez and Derek Doherty 6. Lung pathology 86 Marie-Christine Copin, Jean-Baptiste Gibier, Véronique Hofman and Paul Hofman 7. Clinical features and acute management in adults 101 Nuzhath Khan, Lucy Lamb and Rachel Moores 8. Management in the ICU 124 Sachin Ananth, Avinash Aujayeb, Shari B. Brosnahan, Lieuwe D. Bos, Rebecca F. D’Cruz, Daniel López-Padilla, Anthony Lubinsky, Hrishikesh S. Kulkarni, Toni Marín and Ema Swingwood 9. Clinical features and acute management in children 144 Katherine Longbottom, Elizabeth Whittaker and Justin Penner ERS monograph COVID-19 Number 94 December 2021
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