Contents
Preface v
Guest Editors vii
Introduction ix
List of abbreviations xiv
1. Respiratory failure: a patient’s perspective and clinical cases 1
Francesco Amati, Annalisa Vigni, Sofia Misuraca, Francesco Bindo,
Andrea Gramegna, Antonio Voza, Francesco Blasi and Stefano Aliberti
2. Epidemiology: global spread, risk factors for disease incidence, 14
severity and mortality
Joan B. Soriano and Alberto Infante
3. Historical perspective: other human coronavirus infectious diseases, 28
SARS and MERS
David S. Hui and Alimuddin Zumla
4. Drug repurposing and other strategies for rapid antiviral 39
development: lessons from the early stage of the pandemic
Sophie O’Reilly, Matthew Angeliadis, Ross Murtagh and Virginie W. Gautier
5. Can the immune system be targeted to treat COVID-19? 69
Sarah Abdelhafeez and Derek Doherty
6. Lung pathology 86
Marie-Christine Copin, Jean-Baptiste Gibier, Véronique Hofman and Paul Hofman
7. Clinical features and acute management in adults 101
Nuzhath Khan, Lucy Lamb and Rachel Moores
8. Management in the ICU 124
Sachin Ananth, Avinash Aujayeb, Shari B. Brosnahan, Lieuwe D. Bos,
Rebecca F. D’Cruz, Daniel López-Padilla, Anthony Lubinsky,
Hrishikesh S. Kulkarni, Toni Marín and Ema Swingwood
9. Clinical features and acute management in children 144
Katherine Longbottom, Elizabeth Whittaker and Justin Penner
ERS monograph
COVID-19 Number 94
December 2021
Preface v
Guest Editors vii
Introduction ix
List of abbreviations xiv
1. Respiratory failure: a patient’s perspective and clinical cases 1
Francesco Amati, Annalisa Vigni, Sofia Misuraca, Francesco Bindo,
Andrea Gramegna, Antonio Voza, Francesco Blasi and Stefano Aliberti
2. Epidemiology: global spread, risk factors for disease incidence, 14
severity and mortality
Joan B. Soriano and Alberto Infante
3. Historical perspective: other human coronavirus infectious diseases, 28
SARS and MERS
David S. Hui and Alimuddin Zumla
4. Drug repurposing and other strategies for rapid antiviral 39
development: lessons from the early stage of the pandemic
Sophie O’Reilly, Matthew Angeliadis, Ross Murtagh and Virginie W. Gautier
5. Can the immune system be targeted to treat COVID-19? 69
Sarah Abdelhafeez and Derek Doherty
6. Lung pathology 86
Marie-Christine Copin, Jean-Baptiste Gibier, Véronique Hofman and Paul Hofman
7. Clinical features and acute management in adults 101
Nuzhath Khan, Lucy Lamb and Rachel Moores
8. Management in the ICU 124
Sachin Ananth, Avinash Aujayeb, Shari B. Brosnahan, Lieuwe D. Bos,
Rebecca F. D’Cruz, Daniel López-Padilla, Anthony Lubinsky,
Hrishikesh S. Kulkarni, Toni Marín and Ema Swingwood
9. Clinical features and acute management in children 144
Katherine Longbottom, Elizabeth Whittaker and Justin Penner
ERS monograph
COVID-19 Number 94
December 2021