Contents Preface v Guest Editors vii Introduction ix 1. Prevalence of COPD and comorbidity 1 Shambhu Aryal, Enrique Diaz-Guzman and David M. Mannino 2. COPD: inflammatory mechanisms and systemic consequences 13 Peter J. Barnes 3. Assessment of cardiovascular comorbidity 28 John D. Maclay and William MacNee 4. Diagnosis and management of heart failure in COPD 50 Frans H. Rutten 5. Infection and comorbidity 64 Richa Singh, Alexander J. Mackay and Jadwiga A. Wedzicha 6. Malnutrition and obesity in COPD 80 Erica P.A. Rutten, Emiel F.M. Wouters and Frits M.E. Franssen 7. Osteoporosis in COPD 93 Elisabeth A.P.M. Romme, Frank W.J.M. Smeenk, Emiel F.M. Wouters and Erica P.A. Rutten 8. Gastro-oesophageal reflux disease and COPD 105 Anant R.C. Patel and John R. Hurst 9. Metabolic syndrome and diabetes mellitus in COPD 117 Claire E. Wells and Emma H. Baker 10. Obstructive sleep apnoea and COPD 135 Walter T. McNicholas and Ruth Lee 11. Management of depression and anxiety in COPD 144 Paul A. Cafarella, Tanja W. Effi ng, Christopher Barton, David Ahmed and Peter Anthony Frith 12. Managing skeletal muscle dysfunction in COPD 164 Th ierry Troosters, Wim Janssens and Marc Decramer Number 59 March 2013